THE ROLE OF METAL-BASED DRUGS IN MEDICINAL CHEMISTRY: APPLICATIONS AND CHALLENGES

ARONIMO SAMUEL B.; OLABIMTAN OLABODE H.; BATARI MUSA L.; BALOGUN JOHN O.; SHIRLEY YAKUBU O.; NNENNAYA OLACHI U.; ODEKE EVELYN H.; EGWIM NKECHINYERE N.; ABARI EMMANUEL J.

doi:10.70382/sjhsr.v8i3.032

Authors

ARONIMO SAMUEL B. Kogi State College of Education (Technical), Department of Chemistry, Mopa, Kogi State, Nigeria. Author
OLABIMTAN OLABODE H. National Research Institute for Chemical Technology, Department of Industrial and Environmental Pollution, Zaria Kaduna State, Nigeria. Author
BATARI MUSA L. National Research Institute for Chemical Technology, Department of Scientific and Industrial Research, Zaria Kaduna State, Nigeria. Author
BALOGUN JOHN O. Kogi State College of Education (Technical), Department of Chemistry, Mopa, Kogi State, Nigeria. Author
SHIRLEY YAKUBU O. Federal Polytechnic Kaltungo, Department of Science Laboratory Technology, Gombe State, Nigeria. Author
NNENNAYA OLACHI U. National Research Institute for Chemical Technology, Department of Outstation, Akwa Ibom State, Nigeria. Author
ODEKE EVELYN H. National Research Institute for Chemical Technology, Department of Scientific and Industrial Research, Zaria Kaduna State, Nigeria. Author
EGWIM NKECHINYERE N. National Research Institute for Chemical Technology, Department of Outstation (Entrepreneurial), Aba, Abia State, Nigeria. Author
ABARI EMMANUEL J. Ahmadu Bello University, Faculty of Life Sciences, Department of Microbiology, Zaria, Kaduna State, Nigeria. Author

DOI:

https://doi.org/10.70382/sjhsr.v8i3.032

Keywords:

Metal-Based Drugs, Medicinal Chemistry, Therapeutic Efficacy, Drug Resistance, Toxicity

Abstract

Metal-based drugs are important classes of new drugs in current medicinal chemistry with some different therapeutic profiles compared to organic compounds. This review considers these drugs used in oncology, antimicrobial therapy, and neurodegenerative disease focusing on the cytostatic and antimicrobial effects, the action mechanisms, and problems related to chemotherapy. Information about toxicity, resistance and stability issues is provided together with ideas on how to manage specific difficulties. The review further taps into recent studies and points future of drug design and advanced nanotechnology-based drug delivery techniques.