NEPHRO PROTECTIVE EFFECT OF CAMEL MILK WHEY FRACTION IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Abstract

The aim of this research is to determine the nephron protective effect of camel milk whey fractioning Streptozotocin induced diabetic rats. Whey fraction of camel milk was isolated according to the Standard method described by Moradian et al; 2014. Urea and creatinine concentration in blood plasma were determined according to the standard method described by Searcy et al 1967. Whey fraction was isolated and administered to the whey fraction treated groups. The serum urea levels were 5.13 ± 0.26, 18.77 ± 0.07 10.70 ± 0.16, 12.70 ± 0.06, 11.6 ± 0.02, 10.83 ± 0.07 and 9.60 ±   0.06 for Normal control, Diabetic control. metformin control, 250ml/kgbw, 500ml/kgbw,750ml/kgbw and 1000ml/kgbw respectively. Where the serum creatinine levels were 80.85 ± 0.91, 220.57 ± 4.24 130.00 ± 0.43, 148.86 ± 1.77, 143.29 ± 0.42, 130.71 ± 1.04 and 128.71 ± 0.68 for Normal control, Diabetic control, Metformin control, 250ml/kgbw, 750ml/kgbw and 1000ml/kgbw respectively. This findings may help in reducing the severe effect of diabetic kidney disease and diabetes related diseased since diabetes mellitus is a major cause of kidney disease.